Hydrochlorothiazide remains a viable option for older patients with hypertension, as it is associated with a lower risk of hypokalemia vs. chlorthalidone and is available in more generic single-pill combinations.
Evidence suggests that the harms of gabapentinoid misuse may be greater than originally appreciated. Overuse has been associated with an increase in all-cause hospitalizations, a risk that was found to be three times higher in those concurrently taking high-dose opioids.