In rheumatoid arthritis patients with a history of cardiovascular disease, the risk of major adverse cardiovascular events is higher with tofacitinib than with tumor necrosis factor inhibitors.
Having previously updated the risks specified on the product monograph for one type of Janus Kinase inhibitor, Health Canada now says it can't rule out similar risks for other types.
People who are taking common cardiovascular drugs and given Paxlovid (nirmatrelvir/ritonavir) are at risk of drug-drug interactions, according to a review in the Journal of the American College of Cardiology.