Sandra Knowles
ARTICLES BY THIS AUTHOR
- 9/24/2026
Safety of aluminum-adjuvanted vaccines
Despite decades of post-licensing surveillance showing an excellent safety record, questions continue to arise about the long-term safety of aluminum-adjuvanted vaccines. - 9/24/2026
GLP-1 RAs: risk of pulmonary aspiration
These medications delay gastric emptying, which increases the risk of residual gastric contents despite standard fasting in the perioperative setting. - 5/25/2026
Contraception in women taking teratogenic cardiovascular drugs
Renin-angiotensin system inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, are established teratogens, whereas the teratogenicity of statins is suspected but uncertain. - 5/19/2026
Dependence risk with benzodiazepines, z-drugs and gabapentinoids
In the U.K., safety warnings for benzodiazepines, z-drugs and gabapentinoids have been strengthened. - 1/12/2026
Minocycline-induced lupus
Inappropriate antibiotic prescriptions, due to incorrect drug, dosing or duration, may lead to emergence of multidrug-resistant organisms, adverse drug events and increased healthcare expenditures. - 12/16/2025
VTE risk with newer hormonal contraceptives
Venous thromboembolism is a recognized adverse event linked to hormonal contraceptives, with an increased risk related to higher estrogen dose and progestin type, in particular depot medroxyprogesterone acetate. - 10/23/2025
Amiodarone adverse effects
Amiodarone is an antiarrhythmic drug used to treat various ventricular and atrial tachyarrhythmias. Although it is an effective drug, amiodarone is associated with many different adverse effects, including pulmonary, thyroid, ocular and liver toxicity. - 9/21/2025
Finasteride and suicide ideation
Finasteride, a type 2 5-alpha-reductase inhibitor, is indicated for treatment of benign prostatic hyperplasia and for androgenetic alopecia in men. - 6/26/2025
GLP-1 receptor agonists and pancreatic cancer
This study provides reassuring data that GLP-1 receptor agonists are not associated with an increased risk of pancreatic cancer. - 6/24/2025
Antidepressant-induced weight gain
Antidepressants are commonly used medications, with about 16% of people in Canada using antidepressants in 2023. - 1/20/2025
Adverse drug events in outpatient settings
ADEs in the outpatient setting are common, occuring in approximately 5% of patients. Of these, 22% are considered preventable. - 1/16/2025
Antihypertensives and eczematous dermatitis
Rates of eczematous dermatitis have been increasing among older adults.
