Oct 2023
18 Oct
Hormone replacement therapy and risk of dementia
Some early studies suggested that HRT may have a protective effect on the development of Alzheimer’s disease. In contrast, other research found HRT was associated with a two-fold increased risk of dementia in women aged 65 years or older.
18 Oct
Benzodiazepine-related toxicity: Ontario study
In Canada, the prevalence of benzodiazepine use is estimated between 5% and 10%.
July 2023
24 Jul
Metabolic adverse effects of antipsychotics
A recent network meta-analysis investigated the mid- to long-term metabolic effects of antipsychotics in randomized controlled trials of 13 weeks’ duration or longer in patients with schizophrenia.
18 Jul
Measures to reduce acetaminophen hepatotoxicity
The FDA mandate to limit the dosage of acetaminophen to 325 mg in tablets that combine acetaminophen and opioid medications significantly reduced cases of hospitalizations and serious liver injury.
Apr 2023
11 Apr
Evaluating patients for drug-induced liver injury
Drug-induced liver injury can range from asymptomatic liver enzyme elevation, the most common presentation, to acute liver failure.
11 Apr
Hormone therapy safety in breast cancer survivors
Use of systemic and vaginal estrogens can help to mitigate unwanted effects of adjuvant endocrine therapy; however, concern has been raised regarding a possible increased risk of breast cancer recurrence.
Dec 2022
06 Dec
Do psychotropic medications affect COVID-19 risk?
Persons with serious mental illness are particularly vulnerable to COVID-19.
05 Dec
Melatonin poisonings increasing in children
Melatonin, an endogenous neurohormone that regulates the sleep-wake cycle, is used in the treatment of insomnia in adults and for primary sleep disorders in children.
Sep 2022
19 Sep
Stroke risk with antidopaminergic antiemetics
Antipsychotic medications with centrallyacting antidopaminergic properties (e.g., risperidone, haloperidol) have been shown to increase the risk of ischemic stroke, especially in older patients and patients with dementia.
19 Sep
Tofacitinib: cardiovascular and cancer risks
Janus kinase inhibitors are oral targeted agents used for the treatment of various chronic inflammatory diseases including rheumatoid arthritis, psoriatic arthritis, ulcerative colitis and atopic dermatitis.
May 2022
24 May
Is apixaban preferred over rivaroxaban in AF?
For patients with a higher baseline bleeding risk, apixaban may be a better choice than rivaroxaban.
24 May
Myocarditis/pericarditis risk with COVID-19 vaccines
Cases of myocarditis/ pericarditis following COVID-19 vaccination have generally occurred more frequently in adolescents and young men (
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